Miljöpåverkan
Docetaxel (vattenfri)
Miljörisk:
Risk för miljöpåverkan av docetaxel (vattenfri) kan inte uteslutas då det inte finns tillräckliga ekotoxikologiska data.
Nedbrytning:
Det kan inte uteslutas att docetaxel (vattenfri) är persistent, då data saknas.
Bioackumulering:
Docetaxel (vattenfri) har låg potential att bioackumuleras.
Läs mer
Detaljerad miljöinformation
Miljörisk
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC (μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.5 * 10-6 * 1.7 * (100-0)
Where:
A = 1.7 kg (total sold amount API in Sweden year 2018, data from IQVIA).
R = % removal rate (due to loss by adsorption to sludge particles, by volatilization, hydrolysis or biodegradation) = 0 if no data is available.
P = number of inhabitants in Sweden = 9 *106
V (L/day) = volume of wastewater per capita and day = 200 (ECHA default) (Ref 1)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref 1)
PEC = 2.5 * 10-4 μg/L
According to the European Medicines Agency guideline on environmental risk assessment of medicinal products (EMA/CHMP/SWP/4447/00), use of docetaxel is unlikely to represent a risk for the environment, because the predicted environmental concentration (PEC) is below the action limit 0.01 μg/L.
Predicted No Effect Concentration (PNEC)
No data available so cannot be calculated.
Environmental risk classification (PEC/PNEC ratio)
Cannot be calculated due to unavailable PNEC.
Nedbrytning
No data is available.
Bioackumulering
LogP = 2.83 (Ref 2)
If Log P < 4 at pH 7 the substance has low potential for bioaccumulation.
References
-
ECHA, European Chemicals Agency. 2008 Guidance on information requirements and chemical safety assessment. http://guidance.echa.europa.eu/docs/guidance_document/information_requirements_en.htm.
-
PubChem, 2020-08-05, https://pubchem.ncbi.nlm.nih.gov/compound/148124#section=Octanol-Water-Partition-Coefficient
(Estimated, US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.11. Nov, 2012)