Miljöpåverkan
Fenylpropanolamin
Miljörisk:
Risk för miljöpåverkan av fenylpropanolamin kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att fenylpropanolamin är persistent, då data saknas.
Bioackumulering:
Fenylpropanolamin har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC(μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.37*10-6*A(100-R)
PEC = 0.0198 μg/L
Where:
A = 144.42 kg (total amount API of phenylpropanolamine hydrochloride in Sweden year 2020, data from IQVIA). (Ref. 1)
R = removal rate = 0% (no data available)
P = number of inhabitants in Sweden = 10*106
V (L/day) = volume of waste water per capita and day = 200 (ECHA default) (Ref. 2)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. 2)
Ecotoxicological studies
No ecotoxicological data available.
Degradation
No degradation data available.
Bioaccumulation
An experimentally derived Log P of 0.67 (Ref. 3) indicates that phenylpropanolamine has low potential for bioaccumulation.
Log P < 4 which justifies use of the phrase “Phenylpropanolamine has low potential for bioaccumulation”.
References:
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Data from IQVIA ”Consumption assessment in kg for input to environmental classification v1 - updated 2021 (data 2020)”.
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ECHA, European Chemicals Agency. Guidance on information requirements and chemical safety assessment.
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Biobyte (1995), ChemID+, US National Library of Medicin, National Institutes of Health.