Miljöpåverkan
Metylfenidat
Miljörisk:
Risk för miljöpåverkan av metylfenidat kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att metylfenidat är persistent, då data saknas.
Bioackumulering:
Metylfenidat har låg potential att bioackumuleras.
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Detaljerad miljöinformation
1. PREDICTED ENVIRONMENTAL CONCENTRATION (PEC):
The Predicted Environmental Concentration is calculated according to the following formula:
|
PEC (µg/L) |
= |
A x 109 x (100 - R) / 365 x P x V x D x 100 |
Where:
|
A (kg/year) |
= |
962.17429 kg (total sold amount API in the most recent sales data for Sweden (2019) was distributed by IQVIA/LIF in 2020) |
|
R (%) |
= |
removal rate (due to loss by adsorption to sludge particles, by volatilization, hydrolysis or biodegradation) |
|
= |
0% (worst-case scenario: no removal) |
|
|
P |
= |
number of inhabitants in Sweden (9 x 106) |
|
V (L/day) |
= |
volume of waste water per capita and day |
|
= |
200 (ECHA default) [1] |
|
|
D |
= |
factor for dilution of waste water by surface water flow |
|
= |
10 (ECHA default) [1] |
|
|
PEC (µg/L) |
= |
0.146449664 µg/L |
Ecotoxicological studies:
No ecotoxicological studies available. Therefore, PNEC cannot be calculated.
Risk of environmental impact of Methylphenidate cannot be excluded, since no ecotoxicity data are available.
Degradation:
No data on degradation available.
The potential for persistence of Methylphenidate cannot be excluded, due to lack of data.
2. BIOACCUMULATION
2.1 Partition coefficient octanol/water
The partition coefficient [2]
Experimental value:
log Dow = 0.2
method: unknown
Conclusion for bioaccumulation:
Methylphenidate has low potential for bioaccumulation.
3. REFERENCES
-
ECHA, European Chemicals Agency. 2008 Guidance on information requirements and chemical safety assessment. http://guidance.echa.europa.eu/docs/guidance_document/information_requirements_en.htm
-
ChemIDPlusAdvanced, RN 113-45-1, data is provided by SRC Inc. to ChemIDplus (http://chem.sis.nlm.nih.gov/chemidplus/rn/113-45-1)