Miljöpåverkan (Läs mer om miljöpåverkan)
Cisplatin
Miljörisk:
Risk för miljöpåverkan av cisplatin kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att cisplatin är persistent, då data saknas.
Bioackumulering:
Cisplatin har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Bioaccumulation
Log POW for Cisplatin = -2.35±0.10 (Feng et. al., Cancer Chemother Pharmacol (2004) 54: 441–448)
Measurement of the partition coefficient (Feng et. al., Cancer Chemother Pharmacol (2004) 54: 441–448):
The partition coefficient was measured using a two phase system composed of 1-octanol (HPLC grade, from Aldrich, Milwaukee, Wis.) as the organic phase, and DI water (HPLC grade, from Fischer Scientific) as the aqueous phase. To measure the partition coefficient of cisplatin, 4 mg cisplatin was dissolved in 4 ml DI water and the resulting solution was mixed with 4 ml 1-octanol. Upon mixing, the solutions were vortexed at the maximum speed (VWR Vortexer 2, Model G-560, Bohemia, NY) for 15 s every 5 min, and 30 min later, the solutions were centrifuged at 3000 g for 10 min. Samples from both the aqueous phase and the organic phase were then collected and analyzed for Pt concentration by atomic absorbance (AA) spectrophotometry. The partition coefficient was calculated by determining the ratio between the concentration of Pt in the organic phase and that in the aqueous phase.
As log POW is below 4.5 no screening for persistence, bioaccumulation and toxicity according to EU TGD is required.
References
Feng et. al., Cancer Chemother Pharmacol (2004) 54: 441–448