Miljöpåverkan (Läs mer om miljöpåverkan)
Ampicillin
Miljörisk:
Risk för miljöpåverkan av ampicillin kan inte uteslutas då det inte finns tillräckliga ekotoxikologiska data.
Nedbrytning:
Det kan inte uteslutas att ampicillin är persistent, då data saknas.
Bioackumulering:
Ampicillin har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Detailed background information
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC(μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.5*10-6*A(100-R)
PEC = 0,026 μg/L
Where:
A = 174,3970 kg (total amount API of ampicillin sodium in Sweden year 2017, data from IQVIA) (Ref.1).
R = removal rate = 0% (no data available)
P = number of inhabitants in Sweden = 9*106
V (L/day) = volume of waste water per capita and day = 200 (ECHA default) (Ref. 2)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. 2)
Ecotoxicological studies
Fresh water green algae (Chlorella vulgaris) (ref. 3)
NOEC 72h (growth inhibition): >1000 mg/L (OECD 201)
Fresh water green algae (Selenastrum capricornutum) (Ref. 3)
NOEC 72h (growth inhibition): >1000 mg/L (OECD 201)
Risk of environmental impact of ampicillin cannot be excluded, since there is not sufficient ecotoxicity data available.
Degradation
No degradation data available.
Bioaccumulation
An experimentally derived Log Pow of 1,35 (unknown method) (Ref. 4) indicates that ampicillin has low potential for bioaccumulation.
Log Pow < 4 which justifies the phrase “Ampicillin has low potential for bioaccumulation”.
References:
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Data from IQVIA “Consumption assessment in kg for input to environmental classification – updated 2018 (data 2017)
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ECHA, European Chemicals Agency. Guidance on information requirements and chemical safety assessment. Ver 2.1, 2011
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Eguchi K. et al. Evaluation of antimicrobial agents for veterinary use in the ecotoxicity test using microalgae. Chemosphere2004v57 p1733-1738
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Sangster (1994), ChemID+, US National Library of Medicin, National Institutes of Health