FASS logotyp
Receptbelagd

Peka på symbolerna och beteckningarna till vänster för en förklaring.

Kontakt

Sök apotek med läkemedlet i lager

Sök lagerstatus

Propavan

Sanofi AB

Tablett 25 mg
(vita - gulvita, runda, kupade med brytskåra, 9 mm)

Sömnmedel

Aktiv substans:
ATC-kod: N05CM06
Utbytbarhet: Ej utbytbar
Läkemedel från Sanofi AB omfattas av Läkemedelsförsäkringen.
  • Vad är miljöinformation?

Miljöinformation

Miljöpåverkan

Propiomazin

Miljörisk: Risk för miljöpåverkan av propiomazin kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning: Det kan inte uteslutas att propiomazin är persistent, då data saknas.
Bioackumulering: Propiomazin har hög potential att bioackumuleras.


Läs mer

Detaljerad miljöinformation


Environmental risk classification

Predicted environmental concentration (PEC)

PEC is calculated according to the following formula:

PEC (µg/l) = (A*109(100-R))/(365*P*V*D*100) = 1.5*10-6A*(100-R)


PEC = 0.243 µg/L


Where:

A = 1621,1761 kg (total sold amount API in Sweden year 2017, data from IQVIA)

R = 0 % removal rate (due to loss by adsorption to sludge particles, by

volatilization, hydrolysis or biodegradation)

P = number of inhabitants in Sweden = 9*106

V (L/day) = volume of wastewater per capita and day = 200 (Ref I)

D = factor of dilution of waste water by surface water flow = 10 (Ref I)


Predicted no effect concentration (PNEC)

Ecotoxicological studies

No data available.


Environmental risk classification (PEC/PNEC ratio)

The PEC/PNEC ratio could not be determined since no ecotoxicological test results are available, hence justifies for the environmental risk standard phrase: "risk of environmental impact of propiomazine cannot be excluded, since no ecotoxicity data are available".



Degradation

No degradation data are available. Therfore, the summary phrase for degradation to be used is: "the potential for persistence of propiomazine cannot be excluded, due to lack of data".


Bioaccumulation

Log Pow = 4.79 (experimentally determined with unknown method) (Ref II)

Since log Pow > 4, propiomazine has high potential for bioaccumulation.


Excretion

No recent information is available on compound excretion.

Three metabolites have been identified: a ring hydroxylated metabolite, a sulfoxide metabolite, and a N-demethylpropiomazine (Ref III).


References

  1. ECHA, European Chemicals Agency, 2008. Guidance on information requirements and chemical safety assessment.

  2. Hansch C., et al. 1995, Chem ID+, US National Library of Medicine, National Institute of Health, http://chem.sis.nlm.nih.gov

  3. Micromedex at: https://www.micromedexsolutions.com