Miljöpåverkan
Pemigatinib
Miljörisk:
Risk för miljöpåverkan av pemigatinib kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att pemigatinib är persistent, då data saknas.
Bioackumulering:
Pemigatinib har låg potential att bioackumuleras.
Läs mer
Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC (μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.37*10-6*A(100-R)
PEC = 0.00000031 μg/L
Where:
A = 0.002268 kg (total sold amount API in Sweden year 2022, data from IQVIA) (Ref I).
R = 0 % removal rate
P = number of inhabitants in Sweden = 10 *106
V (L/day) = volume of wastewater per capita and day = 200 (ECHA default) (Ref. II)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. II)
Predicted No Effect Concentration (PNEC)
Risk of environmental impact of pemigatinib cannot be excluded, since no ecotoxicity data are available.
Degradation
The potential for persistence of pemigatinib cannot be excluded, due to lack of data.
Bioaccumulation
Partitioning coefficient:
e.g. Log Dow = 1.53 at pH 7.4 (Ref III)
Justification of chosen bioaccumulation phrase: Since log Dow < 4 at pH 7.4, the substance has low potential for bioaccumulation.
References
-
Data from IQVIA ”Consumption assessment in kg for input to environmental classification v1 - updated 2023 (data 2022)”.
-
ECHA, European Chemicals Agency. 2008 Guidance on information requirements and chemical safety assessment.
-
Chemspider. 2023. https://www.chemspider.com/Chemical-Structure.68007304.html