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Suxamethonium Aguettant

Miljöinformation
Receptstatus
Förmånsstatus
Laboratoire Aguettant

Injektionsvätska, lösning i förfylld spruta 10 mg/ml
(Klar och färglös lösning.)

tablettbild

muskelavslappande medel, perifert verkande; kolinderivat.

Aktiv substans:
ATC-kod: M03AB01
Utbytbarhet: Ej utbytbar
Läkemedel från Laboratoire Aguettant omfattas av Läkemedelsförsäkringen.
  • Vad är miljöinformation?

Miljöinformation

Miljöpåverkan

Suxametonium

Miljörisk: Risk för miljöpåverkan av suxametonium kan inte uteslutas då det inte finns tillräckliga ekotoxikologiska data.
Nedbrytning: Det kan inte uteslutas att suxametonium är persistent, då data saknas.
Bioackumulering: Suxametonium har låg potential att bioackumuleras.


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Detaljerad miljöinformation

Environmental Risk Classification

Predicted Environmental Concentration (PEC)

PEC is calculated according to the following formula:

PEC (μg/L) = calculated with F pen refined (2018 draft guideline)

PEC = 0.0027 μg/L

Where:

ekvation

With :

DOSEai = Maximum daily dose consumed per inhabitant = 100 mg


Fpen = Percentage of market penetration = 0.01


WASTEWinhab = Amount of wastewater per inhabitant per day = 200 L/inh/day


DILUTION = dilution factor = 10


PECSURFACEWATER= 0.5 µg/L


Since this value is higher than 0.01 µg/L a Fpen refined has been used.

ekvation 2

With :

PREGION Prevalence for the region = 0.02

tTreatment Duration of one period treatment : ll type of surgery are performed in one day

nTreatment Number of treatment / year : as calculated : 1

Nd : Number of day / year : 365


           Fpen refined=0.02x1x1/365

           Fpen refined = 0.0000548


PECSURFACEWATER=(100 x 0.0000548)/(200 x 10)

PECSURFACEWATER = 0.0027 µg/L


Log Kow:

The partition coefficient experimental determination could not have been determined with the OECD Guidelines due to the stability and the solubility of the product but there are values for log Kow found in the literature:

  • The log Kow from the EPA (Environmental United States Protection Agency) is evaluated at -4.

  • The calculated log Kow by the ACD/Chemsketch software is -5.9.

Litterature data show that the Log Kow of suxamethonium chloride is highly negative, the substance is therefore considered to have low potential for bioaccumulation.


References

  1. Abbott TEF., Fowler AJ., Dobbs TD., Harrison EM., Gillies MA., Pearse RM. Frequencyof surgical treatment and related hospital procedures in the UK: a national ecological study using hospital episode statistics. Brit. J Anaesth. 2017; 119(2): 249–57

  2. Bitter DB - Institute of Biochemistry, Food Science and Nutrition, Faculty of Agriculture, The Hebrew University of Jerusalem – Succinylcholine Chloride – 2018

  3. CTS 2018 – Surgery and the NHS in numbers - https://www.rcseng.ac.uk/news-andevents/media-centre/media-background-briefings-and-statistics/surgery-and-the-NHSin-numbers/

  4. EPA 2018 https://comptox.epa.gov/dashboard/dsstoxdb/results?utf8=%E2%9C%93&search=306-40-1

  5. MHRA 2018 – Public Assessment Report – UKPAR - Suxamethonium chloride 50mg§/mL solution for injection (suxamethonium chloride) – UK Licence No: PL00156/0110 – Dated 03 August 2018.

  6. Experimental report. Report RP-CRR-1324/2 – Partition coefficient determination report for suxamethonium hydrochloride, 2H2O in the mix Water/Octanol. Date 02/10/2018.

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