Miljöpåverkan
Lidokain
Miljörisk:
Risk för miljöpåverkan av lidokain kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att lidokain är persistent, då data saknas.
Bioackumulering:
Lidokain har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC (μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.37*10-6*A(100-R)
PEC = 0.29 μg/L
Where:
A = 2112.655 kg (1237.9284 kg lidocaine, 863.4509 lidocaine hydrochloride monohydrate and 11.2757 lidocain hydrochloride) (total sold amount API in Sweden year 2021, data from IQVIA). (Ref I)
R = 0 % removal rate
P = number of inhabitants in Sweden = 10 *106
V (L/day) = volume of wastewater per capita and day = 200 (ECHA default) (Ref. II)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. II)
Environmental risk classification (PEC/PNEC ratio)
Risk of environmental impact of lidocaine cannot be excluded, since no ecotoxicity data are available.
Degradation
The potential for persistence of lidocaine cannot be excluded, due to lack of data.
Bioaccumulation
Partitioning coefficient:e.g. Log Dow = 1.26 at pH 7.4. (Ref III)
Justification of chosen bioaccumulation phrase:
Since log Dow < 4 at pH 7, the substance has low potential for bioaccumulation.
References
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Data from IQVIA ”Consumption assessment in kg for input to environmental classification, updated 2022 (data 2021)”.
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ECHA, European Chemicals Agency. 2008 Guidance on information requirements and chemical safety assessment. http://guidance.echa.europa.eu/docs/guidance_document/information_requirements_en.htm
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Hazardous Substances Data Bank (HSDB). Hazardous Substance Data Bank number: 3548. http://www.chemspider.com/Chemical-Structure.3548.html