Miljöpåverkan
radium(Ra-223)diklorid
Miljörisk:
Användning av radium(ra-223)diklorid bedöms inte medföra någon miljöpåverkan.
Läs mer
Detaljerad miljöinformation
Detailed background information
Ra-223 dichloride qualifies as an exempted substance according to the FASS guidance (reference I) due to rapid decay into a stable, naturally occurring element (lead, Pb).
In addition, according to the European Medicines Agency guideline on environmental risk assessments for pharmaceuticals (EMA/CHMP/SWP/4447/00), vitamins, electrolytes, amino acids, peptides, proteins, carbohydrates, lipids, vaccines and herbal medicinal products are exempted because they are unlikely to result in significant risk to the environment. This includes naturally occurring elements such as lead.
The decay of the radionuclide Ra-223 dichloride is shown in the figure below. Ra-223 dichloride has a decay half-life of 11.4 days, while the decay half-live of the decay products are in the range of a few minutes or seconds as indicated in the figure. The stable final decay product Pb-207 (reference II) is a naturally occurring element. In conclusion, Ra-223 dichloride qualifies as an exempted substance according to the FASS guidance (reference I).
References
-
Environmental classification of pharmaceuticals at www.fass.se. Guidance for pharmaceutical companies. V3.0, 2021.
-
Vértes, A.; Nagy, S.; Klencsár, Z.; Lovas, R. G.; Rösch, F., Hrsg., Handbook of Nuclear Chemistry, 2. Aufl.; Springer: Berlin, (2011); Bd. 2, S. 679