Miljöpåverkan
Miljöinformationen för fluorouracil är framtagen av företaget Teva för Fluorouracil Teva
Miljörisk:
Risk för miljöpåverkan av fluorouracil kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att fluorouracil är persistent, då data saknas.
Bioackumulering:
Fluorouracil har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Miljörisk
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC (μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.37 * 10-6 * 117.5 * (100-0)
Where:
A = 146,9 kg (total sold amount API in Sweden year 2021, data from IQVIA).
R = % removal rate (due to loss by adsorption to sludge particles, by volatilization, hydrolysis or biodegradation) = 0 if no data is available.
P = number of inhabitants in Sweden = 10*106
V (L/day) = volume of wastewater per capita and day = 200 (ECHA default) (Ref 1)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref 1)
PEC = 0.020 μg/L
Predicted No Effect Concentration (PNEC)
No data available so cannot be calculated.
Environmental risk classification (PEC/PNEC ratio)
Cannot be calculated due to unavailable PNEC.
Nedbrytning
No data is available.
Bioackumulering
LogP = -0.89 (Ref 2)
If Log P < 4 at pH 7 the substance has low potential for bioaccumulation.
References
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ECHA, European Chemicals Agency. 2008 Guidance on information requirements and chemical safety assessment. http://guidance.echa.europa.eu/docs/guidance_document/information_requirements_en.htm.
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PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/3385#section=Octanol-Water-Partition-Coefficient, 2020
(Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 7)