Miljöpåverkan
Mesalazin
Miljörisk:
Risk för miljöpåverkan av mesalazin kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att mesalazin är persistent, då data saknas.
Bioackumulering:
Mesalazin har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC (μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.37*10-6*A(100-R)
PEC = 5.1810 μg/L
Where:
A = 37817.8710 kg (total sold amount mesalazin in Sweden year 2023, data from IQVIA).
R = 0 % removal rate (due to loss by adsorption to sludge particles, by volatilization, hydrolysis or biodegradation)
P = number of inhabitants in Sweden = 10 *106
V (L/day) = volume of wastewater per capita and day = 200 (ECHA default) (Ref. I)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. I)
Predicted No Effect Concentration (PNEC)
There is no Ecotoxicity data available.
Environmental risk classification (PEC/PNEC ratio)
Justification to chosen risk classification phrase:
The risk of environmental impact of mesalazin cannot be excluded, since no ecotoxicity data are available.
Degradation
Justification to chosen degradation phrase:
The potential for persistence of mesalazin cannot be excluded, due to lack of data.
Bioaccumulation
Log Dow (pH 7.4) = -1.98 (Ref II). Method unknown.
Since log Dow < 4 at pH 7, the substance has low potential for bioaccumulation.
References
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ECHA, European Chemicals Agency. 2008 Guidance on information requirements and chemical safety assessment. http://guidance.echa.europa.eu/docs/guidance_document/information_requirements_en.htm
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Chemspider.
https://www.chemspider.com/Chemical-Structure.3933.html