Miljöpåverkan
Lerkanidipin
Miljörisk:
Risk för miljöpåverkan av lerkanidipin kan inte uteslutas då det inte finns tillräckliga ekotoxikologiska data.
Nedbrytning:
Det kan inte uteslutas att lerkanidipin är persistent, då data saknas.
Bioackumulering:
Lerkanidipin har hög potential att bioackumuleras.
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Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC (μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.37*10-6*A(100-R)
PEC = 0.037 μg/L
Where:
A = 266.8241 kg (total sold amount API in Sweden year 2021, data from IQVIA). Reduction of A may be justified based on metabolism data.
R = X % removal rate (due to loss by adsorption to sludge particles, by volatilization, hydrolysis or biodegradation) = 0 if no data is available.
P = number of inhabitants in Sweden = 10 *106
V (L/day) = volume of wastewater per capita and day = 200 (ECHA default) (Ref. I)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. I)
Bioaccumulation
Log Dow = 5.88 at pH 7.4 (Reference II)
Justification of chosen bioaccumulation phrase:
Since log Dow < 4 at pH 7, the substance has high potential for bioaccumulation.
References
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ECHA, European Chemicals Agency. 2008 Guidance on information requirements and chemical safety assessment. http://guidance.echa.europa.eu/docs/guidance_document/information_requirements_en.htm
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Chemspider. 2023 http://www.chemspider.com/Chemical-Structure.59276.html