Miljöpåverkan
Orfenadrin
Miljörisk:
Risk för miljöpåverkan av orfenadrin kan inte uteslutas då det inte finns tillräckliga ekotoxikologiska data.
Nedbrytning:
Det kan inte uteslutas att orfenadrin är persistent, då data saknas.
Bioackumulering:
Orfenadrin har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC (μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.37*10-6*A(100-R)
PEC = 0.034 μg/L
Where:
A = 245.016 kg (total amount API of orphenadrine citrate in Sweden year 2023, data from IQVIA) (Ref. 1)
R = removal rate = 0% (no data available)
P = number of inhabitants in Sweden = 10*106
V (L/day) = volume of waste water per capita and day = 200 (ECHA default) (Ref. 2)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. 2)
Ecotoxicological studies
Crustacean (Daphnia magna) (Ref. 3)
EC50 24 hours (immobility): 8.87 mg/L (OECD 202, 1980)
Crustacean (Daphnia magna) (Ref. 4)
EC50 24 hours (immobility): 12.6 mg/L (OECD 202, 1984)
Risk of environmental impact of orphenadrine cannot be excluded, since there is not sufficient ecotoxicity data available.
Degradation
No degradation data available.
Bioaccumulation
An experimentally derived Log Kow of 3.77 (unknown method) (Ref. 5) indicates that orphenadrine has low potential for bioaccumulation.
Log Kow < 4 which justifies the phrase “Orphenadrine has low potential for bioaccumulation”.
References:
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Data from IQVIA ”Consumption assessment in kg for input to environmental classification - updated 2024 (data 2023)”.
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ECHA, European Chemicals Agency. Guidance on information requirements and chemical safety assessment. Ver 2.1, 2011.
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Lilius, H et al. (1994), Aquatic Toxocology 30 p47-60
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Calleja M C et al. (1994), Archives of Environmental Contamination and Toxicology, v26, issue 1, p69-78
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Sangster (1993), ChemID+, US National Library of Medicin, National Institutes of Health