Miljöpåverkan
Fenoximetylpenicillin
Miljörisk:
Risk för miljöpåverkan av fenoximetylpenicillin kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att fenoximetylpenicillin är persistent, då data saknas.
Bioackumulering:
Fenoximetylpenicillin har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC (μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.37*10-6*A(100-R)
PEC = 1.6 μg/L
Where:
A = 11 961.01 kg (total sold amount API of phenoxymethylpenicillin potassium in Sweden year 2020, data from IQVIA) (Ref. 1)
R = removal rate = 0% (no data available)
P = number of inhabitants in Sweden = 10*106
V (L/day) = volume of waste water per capita and day = 200 (ECHA default) (Ref. 2)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. 2)
Ecotoxicological studies
No ecotoxicological data available.
Degradation
No degradation data available.
Bioaccumulation
An experimentally derived log Kow of 2.09 (unknown method) (Ref. 3) indicates that phenoxymethylpenicillin has low potential for bioaccumulation.
Log Kow < 4 which justifies use of the phrase “Phenoxymethylpenicillin has low potential for bioaccumulation”.
Excretion (metabolism)
Phenoxymethylpenicillin is excreted mainly in the urine where 30-50% of an administered dose is detectable in an antibacterial active form within 8 hours. (Ref. 4)
References:
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Data from IQVIA ”Consumption assessment in kg for input to environmental classification - updated 2021 (data 2020)”.
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ECHA, European Chemicals Agency. Guidance on information requirements and chemical safety assessment. Ver 2.1, 2011
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Hansch C et al. (1995), ChemID+, US National Library of Medicin
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SPC (Summary of Product Characteristics) Kåvepenin, 2015-04-10, FASS.se