Miljöpåverkan
Metolazon
Miljörisk:
Risk för miljöpåverkan av metolazon kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att metolazon är persistent, då data saknas.
Bioackumulering:
Metolazon har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC(μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1,37*10-6*A(100-R)
PEC = 0,00022μg/L
Where:
A = 1,6377 kg (total sold amount API in Sweden year 2021, data from IQVIA).
R = removal rate = 0% (no data available)
P = number of inhabitants in Sweden = 10*106
V (L/day) = volume of waste water per capita and day = 200 (ECHA default) (Ref. 1)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. 1)
Ecotoxicological studies
No ecotoxicological data available.
Degradation
No degradation data available.
Bioaccumulation
Partitioning coefficient
An experimentally derived Log Kow of 1,84 (unknown method) (Ref. 2) indicates that metolazone has low potential for bioaccumulation.
Log Kow < 4 which justifies use of the phrase “Metolazone has low potential for bioaccumulation”.
References
1. ECHA, European Chemicals Agency. Guidance on information requirements and chemical safety assessment. Ver 2.1, 2011.
http://echa.europa.eu/documents/10162/13643/information_requirements_r2_en.pdf
2. Meylan WM and Howard PH (1995), ChemID+, US National Library of Medicine, National Institutes of Health,
http://chem.sis.nlm.nih.gov/chemidplus/chemidheavy.jsp