Miljöpåverkan
Miljöinformationen för dexametason är framtagen av företaget Abcur för Dexametason Abcur
Miljörisk:
Risk för miljöpåverkan av dexametason kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att dexametason är persistent, då data saknas.
Bioackumulering:
Dexametason har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC(μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1,37*10-6*A(100-R)
PEC 0,000601μg/L
Where:
A = 4,3866 kg (total sold amount API in Sweden year 2021, data from IQVIA).
R = removal rate = 0% (no data available)
P = number of inhabitants in Sweden = 10*106
V (L/day) = volume of waste water per capita and day = 200 (ECHA default) (Ref. 1)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. 1)
Ecotoxicological studies
No ecotoxicological data available.
Degradation
No degradation data available.
Bioaccumulation
Partitioning coefficient
An experimentally derived Log Kow of 1,83 (unknown method) (Ref. 2) indicates that Dexamethasone has low potential for bioaccumulation.
Log Kow < 4 which justifies use of the phrase “Dexamethasone has low potential for bioaccumulation”.
References
1. ECHA, European Chemicals Agency. Guidance on information requirements and chemical safety assessment. Ver 2.1, 2011.
http://echa.europa.eu/documents/10162/13643/information_requirements_r2_en.pdf
2. Hansch C et al (1995), ChemID+, US National Library of Medicine, National Institutes of Health,
http://chem.sis.nlm.nih.gov/chemidplus/chemidheavy.jsp