Miljöpåverkan
Mesalazin
Miljörisk:
Risk för miljöpåverkan av mesalazin kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att mesalazin är persistent, då data saknas.
Bioackumulering:
Mesalazin har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Risk of environmental impact cannot be excluded, since no ecotoxicity data are available
PEC = 3,33 μg/L
PEC is based on the formula:
PEC (µg/L) = (A*109*(100-R))/(365*P*V*D*100)
Where:
A = 24336 kg (total sold amount API in Sweden year 2019, data from IQVIA). Reduction of A may be justified based on metabolism data.
R = X % removal rate (due to loss by adsorption to sludge particles, by volatilization, hydrolysis or biodegradation) = 0 if no data is available.
P = number of inhabitants in Sweden = 10*106
V (L/day) = volume of wastewater per capita and day = 200
(ECHA default) (Ref. I)
D = factor for dilution of waste water by surface water flow = 10
(ECHA default) (Ref. I)
Bioaccumulation
Partitioning coefficient (Ref. II)
Log Kow = 0.98 (est)
Justification of chosen bioaccumulation phrase:
Since log Kow < 4 the substance has low potential for bioaccumulation
References
I. ECHA, European Chemicals Agency. 2008 Guidance on information requirements and chemical safety assessment.
http://guidance.echa.europa.eu/docs/guidance_document/information_requirements_en.htm
II. US EPA; Estimation Program Interface (EPI) Suite. Ver.3.12. Nov 30, 2004. Available from, as of Jan 4, 2007: http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm