Miljöpåverkan
Metadon
Miljörisk:
Risk för miljöpåverkan av metadon kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att metadon är persistent, då data saknas.
Bioackumulering:
Metadon har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC(μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1,37*10-6*A(100-R)
PEC = 0,0138μg/L
Where:
A = 100,7721 kg (total sold amount API in Sweden year 2021, data from IQVIA).
R = removal rate = 0% (no data available)
P = number of inhabitants in Sweden = 10*106
V (L/day) = volume of waste water per capita and day = 200 (ECHA default) (Ref. 1)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. 1)
Ecotoxicological studies
No ecotoxicological data available.
Degradation
No degradation data available.
Bioaccumulation
Partitioning Coefficient
An experimentally derived Log Kow of 3,93 (unknown method) (Ref. 2) indicates that Methadone has low potential for bioaccumulation.
Log Kow < 4 which justifies use of the phrase “Methadone has low potential for bioaccumulation”.
References:
1. ECHA, European Chemicals Agency. Guidance on information requirements and chemical safety assessment. Ver. 2.1, 2011.
http://echa.europa.eu/documents/10162/13643/information_requirements_r2_en.pdf
2. Hansch C et al (1995), Pub Chem, US National Library of Medicine, National Center for Biotechnology Information (NCBI).
https://pubchem.ncbi.nlm.nih.gov/compound/4095#section=Experimental-Properties