Miljöpåverkan
Etylmorfin
Miljörisk:
Risk för miljöpåverkan av etylmorfin kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att etylmorfin är persistent, då data saknas.
Bioackumulering:
Etylmorfin har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC(μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.37*10-6*A(100-R)
PEC = 0.015 μg/L
Where:
A = 109.24 kg (total amount API of ethylmorphine hydrochloride in Sweden year 2020, data from IQVIA). (Ref. 1)
R = removal rate = 0% (no data available)
P = number of inhabitants in Sweden = 10*106
V (L/day) = volume of waste water per capita and day = 200 (ECHA default) (Ref. 2)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. 2)
Ecotoxicological studies
No ecotoxicological data available.
Degradation
No degradation data available.
Bioaccumulation
An estimated Log P of 1.77 (Ref. 3) indicates that ethylmorphine has low potential for bioaccumulation.
Log P < 4 which justifies use of the phrase “Ethylmorphine has low potential for bioaccumulation”.
Excretion (metabolism)
Ethylmorphine is metabolised through N-demethylation to norethylmorphine and through O-deethylation to morphine, reactions catalysed by different forms of cytochrome P450 (CYP 2D6 and CYP 3A4).
Ethylmorphine and its metabolites are mainly excreted via the kidneys as conjugates with glucoronic acid. After 48 hours, about 70% of a given dose was found in the urine. (Ref. 4)
References:
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Data from IQVIA ”Consumption assessment in kg for input to environmental classification v1 - updated 2021 (data 2020)”.
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ECHA, European Chemicals Agency. Guidance on information requirements and chemical safety assessment.
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Meylan WM and Howard PH (1995), ChemID+, US National Library of Medicin, National Institutes of Health.
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SPC (Summary of Product Characteristics) Cocillana-Etyfin, 2018-07-25, FASS.se