Miljöpåverkan
Dinoproston
Miljörisk:
Risk för miljöpåverkan av dinoproston kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att dinoproston är persistent, då data saknas.
Bioackumulering:
Det kan inte uteslutas att dinoproston kan bioackumuleras, då data saknas.
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Detaljerad miljöinformation
According to the European Medicines Agency guideline on environmental risk assessment of medicinal products (EMA/CHMP/SWP/4447/00), use of dinoproston is unlikely to represent a risk for the environment, because the predicted environmental concentration (PEC) is below the action limit 0.01 μg/L.
PEC = 0,0000021915 μg/L
PEC is based on the formula:
PEC (µg/L) = (A*109*(100-R))/(365*P*V*D*100)
Where:
A = 0,01461 kg (total sold amount API in Sweden year 2019, data from IQVIA). Reduction of A may be justified based on metabolism data.
R = X % removal rate (due to loss by adsorption to sludge particles, by volatilization, hydrolysis or biodegradation) = 0 if no data is available.
P = number of inhabitants in Sweden = 9 *106
V (L/day) = volume of wastewater per capita and day = 200
(ECHA default) (Ref. I)
D = factor for dilution of waste water by surface water flow = 10
(ECHA default) (Ref. I)
Ingen PEC/PNEC tillgänglig. PEC ligger under (0,01µg/L).
Degradation
No degradation data available.
Bioaccumulation
No bioaccumulation data available.
References
I. ECHA, European Chemicals Agency. 2008 Guidance on information requirements and chemical safety assessment.
http://guidance.echa.europa.eu/docs/guidance_document/information_requirements_en.htm