Miljöpåverkan
Metadon
Miljörisk:
Risk för miljöpåverkan av metadon kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att metadon är persistent, då data saknas.
Bioackumulering:
Metadon har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Detailed background information
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC(μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.5*10-6*A(100-R)
PEC = 0.014 μg/L
Where:
A = 96.59 kg (total amount API of methadone (methadone hydrochloride, levomethadone hydrochloride) in Sweden year 2020, data from IQVIA) (Ref.1).
R = removal rate = 0% (no data available)
P = number of inhabitants in Sweden = 9*106
V (L/day) = volume of waste water per capita and day = 200 (ECHA default) (Ref.2)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref.2)
Ecotoxicological studies
No ecotoxicological data available.
Degradation
No degradation data available.
Bioaccumulation
An experimentally derived Log Pow of 3.93 (unknown method) (Ref.3) indicates that methadone has low potential for bioaccumulation.
Log Pow < 4 which justifies use of the phrase “Methadone has low potential for bioaccumulation”.
References:
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Data from IQVIA “Consumption assessment in kg for input to environmental classification – updated 2021 (data 2020)
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ECHA, European Chemicals Agency. Guidance on information requirements and chemical safety assessment. Ver 2.1, 2011
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Hansch C et al. (1995), ChemID+, US National Library of Medicin, National Institutes of Health