Miljöpåverkan
Miljöinformationen för epirubicin är framtagen av företaget Teva för Epirubicin Teva
Miljörisk:
Risk för miljöpåverkan av epirubicin kan inte uteslutas då det inte finns tillräckliga ekotoxikologiska data.
Nedbrytning:
Det kan inte uteslutas att epirubicin är persistent, då data saknas.
Bioackumulering:
Epirubicin har låg potential att bioackumuleras.
Läs mer
Detaljerad miljöinformation
Miljörisk
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC (μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.5 * 10-6 * kg * (100-0)
Where:
A = 0,54919 kg (total sold amount API in Sweden year 2020, data from IQVIA).
R = % removal rate (due to loss by adsorption to sludge particles, by volatilization, hydrolysis or biodegradation) = 0 if no data is available.
P = number of inhabitants in Sweden = 10*106
V (L/day) = volume of wastewater per capita and day = 200 (ECHA default) (Ref 1)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref 1)
PEC = 8,24*10-5 μg/L
Predicted No Effect Concentration (PNEC)
No data available so cannot be calculated.
Environmental risk classification (PEC/PNEC ratio)
Cannot be calculated due to unavailable PNEC.
Nedbrytning
No data is available.
Bioackumulering
Estimated LogKow = 1,85 (Ref 2)
If LogKow < 4 at pH 7 the substance has low potential for bioaccumulation.
Referenser
-
ECHA, European Chemicals Agency. 2008 Guidance on information requirements and chemical safety assessment. http://guidance.echa.europa.eu/docs/guidance_document/information_requirements_en.htm.
-
PubChem, 2021-12-02.
https://pubchem.ncbi.nlm.nih.gov/compound/Epirubicin#section=LogP