Miljöpåverkan
Petidin
Miljörisk:
Risk för miljöpåverkan av petidin kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att petidin är persistent, då data saknas.
Bioackumulering:
Petidin har låg potential att bioackumuleras.
Läs mer
Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC(μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.37*10-6*A(100-R)
PEC = 2.5*10-5 μg/L
Where:
A = 0.18 kg (total sold amount API of pethidine hydrochloride in Sweden year 2020, data from IQVIA) (Ref. 1)
R = removal rate = 0% (no data available)
P = number of inhabitants in Sweden = 10*106
V (L/day) = volume of waste water per capita and day = 200 (ECHA default) (Ref. 2)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. 2)
According to the European Medicines Agency guideline on environmental risk assessment of medicinal products (EMA/CHMP/SWP/4447/00), use of pethidine is unlikely to represent a risk for the environment, because the predicted environmental concentration (PEC) is below the action limit 0.01 μg/L.
Ecotoxicological studies
No ecotoxicological data available.
Degradation
No degradation data available.
Bioaccumulation
An experimentally derived Log Pow of 2.72 (unknown method) (Ref. 3) indicates that pethidine has low potential for bioaccumulation.
Log Pow < 4 which justifies use of the phrase “Pethidine has low potential for bioaccumulation”.
References:
-
Data from IQVIA ”Consumption assessment in kg for input to environmental classification - updated 2021 (data 2020)”.
-
ECHA, European Chemicals Agency. Guidance on information requirements and chemical safety assessment. Ver 2.1, 2011
-
Sangster (1994), ChemID+, US National Library of Medicin, National Institutes of Health