Miljöpåverkan
Miljöinformationen för ibuprofen är framtagen av företaget Recordati för Pedea®
Miljörisk:
Risk för miljöpåverkan av ibuprofen kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att ibuprofen är persistent, då data saknas.
Bioackumulering:
Ibuprofen har låg potential att bioackumuleras.
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Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC (μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.37*10-6*A(100-R)
PEC = 28.94 μg/L
Where:
A = 211 215.6728 kg (210 472.4563 kg ibuprofen, 467.9202 kg dexibuprofen, 275.2963 kg ibuprofen-D,L-lysin) (total sold amount API in Sweden year 2022, data from IQVIA) (Ref I).
R = 0 % removal rate
P = number of inhabitants in Sweden = 10 *106
V (L/day) = volume of wastewater per capita and day = 200 (ECHA default) (Ref. II)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. II)
Predicted No Effect Concentration (PNEC)
Risk of environmental impact of ibuprofen cannot be excluded, since no ecotoxicity data are available.
Degradation
The potential for persistence of ibuprofen cannot be excluded, due to lack of data.
Bioaccumulation
Partitioning coefficient:
e.g. Log Dow = 0.45 at pH 7.4 (Ref III)
Justification of chosen bioaccumulation phrase: Since log Dow < 4 at pH 7.4, the substance has low potential for bioaccumulation.
References
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Data from IQVIA ”Consumption assessment in kg for input to environmental classification v1 - updated 2023 (data 2022)”.
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ECHA, European Chemicals Agency. 2008 Guidance on information requirements and chemical safety assessment.
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Chemspider. 2023. http://www.chemspider.com/Chemical-Structure.3544.html