Miljöpåverkan
Niklosamid (vattenfri)
Miljörisk:
Risk för miljöpåverkan av niklosamid (vattenfri) kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att niklosamid (vattenfri) är persistent, då data saknas.
Bioackumulering:
Det kan inte uteslutas att niklosamid (vattenfri) kan bioackumuleras, då data saknas.
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Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC (μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1.37*10-6*A*(100-R) = 0.000031 μg/L
Where:
A = 0.228 kg (total sold amount API in Sweden year 2022, data from IQVIA / LIF)
R = 0 % removal rate (due to loss by adsorption to sludge particles, by volatilization, hydrolysis or biodegradation) = 0 if no data is available
P = number of inhabitants in Sweden = 10 *106
V (L/day) = volume of wastewater per capita and day = 200 (ECHA default) (Reference I)
D = factor for dilution of wastewater by surface water flow = 10 (ECHA default) (Reference I)
Predicted No Effect Concentration (PNEC)
Ecotoxicological studies*
There is no ecotoxicological data, wherefore the PNEC may not be derived.
Environmental risk classification (PEC/PNEC ratio)
The risk quotient may not be calculated, due to the lack of a PNEC.
Justification of chosen environmental risk phrase:
The lack of data to calculate the PEC/PNEC ratio qualifies for the phrase “Risk of environmental impact of niclosamide cannot be excluded, since no ecotoxicity data are available.”.
Degradation
There is no data on degradation.
Justification of chosen degradation phrase:
The lack of data qualifies for the phrase “The potential for persistence of niclosamide cannot be excluded, due to lack of data.”.
Bioaccumulation
There is no bioaccumulation data.
Justification of chosen bioaccumulation phrase:
The lack of data qualifies for the phrase “The potential for bioaccumulation of niclosamide cannot be excluded, due to lack of data.”.
References
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Guidance on information requirements and Chemical Safety Assessment Chapter R.16: Environmental exposure assessment. V3.0, Feb. 2016.