Miljöpåverkan
Propiomazin
Miljörisk:
Risk för miljöpåverkan av propiomazin kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att propiomazin är persistent, då data saknas.
Bioackumulering:
Propiomazin har hög potential att bioackumuleras.
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Detaljerad miljöinformation
Environmental risk classification
Predicted environmental concentration (PEC)
PEC is calculated according to the following formula:
PEC (µg/L) = (A*109(100-R))/(365*P*V*D*100) = 1.37*10-6A*(100-R)
PEC = 0.207 µg/L
Where:
A = 1507.51 kg (total sold amount API in Sweden year 2020, data from IQVIA)
R = 0 % removal rate (due to loss by adsorption to sludge particles, by
volatilization, hydrolysis or biodegradation) = 0 if no data is available.
P = number of inhabitants in Sweden = 10*106
V (L/day) = volume of wastewater per capita and day = 200 (ECHA default) (Ref. I)
D = factor of dilution of waste water by surface water flow = 10 (ECHA default) (Ref. I)
Predicted no effect concentration (PNEC)
Ecotoxicological studies
No data is available.
Environmental risk classification (PEC/PNEC ratio)
The PEC/PNEC ratio could not be determined since no ecotoxicological test results are available.
Justification of chosen summary phrases for the environmental risk:
Risk of environmental impact of propiomazine cannot be excluded, since no ecotoxicity data are available.
Degradation
No degradation data is available.
Justification of chosen degradation phrase:
The potential for persistence of propiomazine cannot be excluded, due to lack of data.
Bioaccumulation
log P = 4.79 (experimentally determined, BIOBYTE (1995))
(Ref. II)
Justification of chosen bioaccumulation phrase:
Since log P > 4, propiomazine has high potential for bioaccumulation.
Excretion (metabolism)
Metabolism: Unknown, but most likely hepatic as with other phenothiazines.
Elimination: Not available.
(Ref. II)
No full picture of metabolites publicly available.
References