Miljöpåverkan
Amitriptylin
Miljörisk:
Risk för miljöpåverkan av amitriptylin kan inte uteslutas då ekotoxikologiska data saknas.
Nedbrytning:
Det kan inte uteslutas att amitriptylin är persistent, då data saknas.
Bioackumulering:
Amitriptylin har hög potential att bioackumuleras.
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Detaljerad miljöinformation
Environmental Risk Classification
Predicted Environmental Concentration (PEC)
PEC is calculated according to the following formula:
PEC(μg/L) = (A*109*(100-R))/(365*P*V*D*100) = 1,37*10-6*A(100-R)
PEC =0,14545 μg/L
Where:
A = 1061,6781 kg (total sold amount API in Sweden year2021, data from IQVIA).
R = removal rate = 0% (no data available)
P = number of inhabitants in Sweden = 10*106
V (L/day) = volume of waste water per capita and day = 200 (ECHA default) (Ref. 1)
D = factor for dilution of waste water by surface water flow = 10 (ECHA default) (Ref. 1)
Ecotoxicological studies
No ecotoxicological data available.
Degradation
No degradation data available.
Bioaccumulation
Partitioning coefficient
An experimentally derived Log Kow of 4,92 (unknown method) (Ref. 2) indicates that Amitriptyline has high potential for bioaccumulation.
Log Kow > 4 which justifies use of the phrase “Amitriptyline has high potential for bioaccumulation”.
References:
1. ECHA, European Chemicals Agency. Guidance on information requirements and chemical safety assessment. Ver 2.1, 2011.
2. Hansch C et al (1995), Drug Bank, Canada. See section Properties/Experimental Properties.